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Tofranil Tablets Review

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Tofranil is a prescription medication used to treat depression. It is also used with children and the elderly to help treat bedwetting. Tofranil works by elevating chemicals in the brain that affect a person’s mood.





Tofranil comes in several different medication forms; injection, sugar coated tablet, and capsule form.

The tablet comes in 10mg, 25 mg, and 50 mg doses.

The medications main ingredient is imipramine hydrochloride. The inactive ingredients in the tablet form are calcium phosphate, cellulose compounds, docusate sodium, iron oxides, magnesium stearate, polyethylene glycol, povidone, sodium starch glycolate, sucrose, talc, and titanium dioxide.

Injection and capsule forms will have a slight difference in inactive ingredients.


Initially adult patients are started on a 75 to 100 mg per day dosage, while children or older patients may start at 30 to 40 mg per day. If there are no improvements a doctor may increase the dosage. General maintenance levels are considered to be between 50 and 150 mg a day. Dosages over 200 mg are not recommended.3 mg/25 mg

Possible Side Effects

Unlike AnxiClear which doesn’t have any known side effects or interactions with other medication, Tofranil has a concerning list of side effects.

  • abdominal or stomach pain
  • agitation
  • blurred vision
  • burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  • chest pain or discomfort
  • clay-colored stools
  • cold sweats
  • confusion about identity, place, and time
  • continuing ringing or buzzing or other unexplained noise in the ears
  • cough or hoarseness
  • difficulty in passing urine (dribbling)
  • dizziness, faintness, or light headedness when getting up suddenly from a lying or sitting position
  • double vision
  • dry mouth
  • fast, pounding, or irregular heartbeat or pulse
  • fever with or without chills
  • flushed, dry skin
  • general feeling of tiredness or weakness
  • hearing loss
  • inability to move the arms, legs, or facial muscles
  • lack of coordination
  • loss of balance control
  • lower back or side pain
  • mood or mental changes
  • muscle spasm or jerking of all extremities
  • muscle trembling, jerking, or stiffness
  • nightmares
  • pain or discomfort in the arms, jaw, back, or neck
  • painful or difficult urination
  • rapid weight gain
  • redness of the face, neck, arms, and occasionally, upper chest
  • restlessness
  • seizures
  • shakiness and unsteady walk
  • slow speech
  • sore throat
  • stiffness of the limbs
  • stupor
  • sweating
  • swelling of the face, ankles, legs, or hands
  • talking, feeling, and acting with excitement
  • trouble sleeping
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back
  • unusual behavior
  • unusual tiredness or weakness
  • weakness in the arms, hands, legs, or feet
  • yellow eyes or skin

Tofranil also interacts with over 1,000 different medications. 261 of them have serious interactions.


Tofranil in tablet form is an affordable prescription medication costing less than $60 for a 30 day prescription.


Tofranil is a prescription medication; therefore it does not come with any money-back guarantee.

However you can report unwanted side effects or other issues to the FDA. The FDA has established a reporting service called MedWatch. Health care professionals and consumers can call to report any problems they believe may be related to the prescription medication they are using by calling 1-800-FDA-1088.


Tofranil’s long list of adverse side effects can be concerning and may be more than enough to stop a person from taking this medication.

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