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Parnate Review

Editor's Rating:

Parnate is a prescription medication designed to treat depression. The medications purpose is to increase the activity of mood heightening chemicals in the brain. Parnate is rarely used as the first medication in a patient to treat the symptoms of depression. It is suitable for patients who have not responded favorably to other medications.



Parnates active ingredient is tranylcypromine sulfate.  The medication does contain inactive ingredients which consist of cellulose, citric acid, croscamellose sodium, gelatin, lactose, magnesium stearate, talc, titanium dioxide and trace amounts of other inactive ingredients. There are also coloring agents used in Parnate such ask D&C red #7, FD&C blue #2, FD&C red #40, and FD&C yellow #6.


The most effective dosage of Parnate in patients is 30 mg per day. This is given in doses split up throughout the day. Improvements are usually seen within the first 48 hours but it may take up to 3 weeks. If no improvements are seen, the dose may be increased by 10 mg per day up to 60 mg in total.

Possible Side Effects

Patients have reported side effects while taking Parnate.  These side effects may not be tolerable for some people.

  • Insomnia
  • Weakness
  • Tiredness
  • Dry mouth
  • Nausea
  • Abdominal pain
  • Diarrhea or constipations
  • Tachycardia
  • Anorexia
  • Edema
  • Palpitation
  • Blurred vision
  • Sexual impotence

These side effects can be alleviated by lower doses of the medication or by using other suitable medication for specific issues.

There are also more than 30 other possible side effects associated with this medication.  Parnate also interacts with over 900 other medications.

Will This Product Produce Long-Term Results?

Parnate is used for long-term management of depression. Once the medication begins to show improvements in the symptoms of depression a doctor will usually monitor the patient and adjust the medication as needed.


Prices for Parnate vary from pharmacy to pharmacy. The medication can cost from between $57 and $157.  You may be able to find better deals by shopping around at different pharmacies.


Since Parnate is a prescription medication it does not have a guarantee. However, users of the medication can report any adverse symptoms they believe may be related to the medication, directly to the FDA.


Parnate has an extensive list of potential side effects and drug interactions which may cause concern in some patients. The price is high if you are unable to find financial assistance or do not have health insurance. All though the medication may begin to help improve symptoms, maximum results can take as long as 3 weeks.

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